Anti-Mouse CD28 Purified
37.51 단일클론항체는 45kDa의 동종이합체(homodimer)인 생쥐의 CD28 분자와 특이적으로 반응합니다. CD28은 대부분의 흉선세포 및 자연살해세포에서 발현되며, 말초의 CD4+ CD8+ T 림프구에서는 낮은 밀도로 발현됩니다. 또한 활성화된 비장 세포, 비만 세포 및 흉선 세포에서도 발견됩니다. CD28은 T 림프구의 공동자극제이자 CD80(B7-1) 및 CD86(B7-2)에 대한 리간드입니다. CD28 신호전달은 IL-2 및 IL-2 수용체의 발현과 CD3-활성화된 T 림프구의 세포독성을 자극합니다.
37.51 단일클론항체는 T 림프구와 자연 살해 세포의 증식을 촉진하며, 각 세포의 사이토카인 생산을 자극합니다.
- Han SM, Park ES, Park J, Nahmgoong H, Choi YH, Oh J, Yim KM, Lee WT, Lee YK, Jeon YG, Shin KC, Huh JY, Choi SH, Park J, Kim JK, Kim JB. Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice. Nat Commun. 2023 Dec 21;14(1):8512. doi: 10.1038/s41467-023-44181-3. PMID: 38129377; PMCID: PMC10739728.
- Lkhagva-Yondon E, Seo MS, Oh Y, Jung J, Jeon E, Na K, Yoo HS, Kim WC, Esser C, Song SU, Jeon MS. The aryl hydrocarbon receptor controls mesenchymal stromal cell-mediated immunomodulation via ubiquitination of eukaryotic elongation factor-2 kinase. Cell Death Dis. 2023 Dec 9;14(12):812. doi: 10.1038/s41419-023-06341-7. PMID: 38071243; PMCID: PMC10710493.
- Choi JH, Lee BS, Jang JY, Lee YS, Kim HJ, Roh J, Shin YS, Woo HG, Kim CH. Single-cell transcriptome profiling of the stepwise progression of head and neck cancer. Nat Commun. 2023 Feb 24;14(1):1055. doi: 10.1038/s41467-023-36691-x. PMID: 36828832; PMCID: PMC9958029.
- Li P, Zhou D, Chen D, Cheng Y, Chen Y, Lin Z, Zhang X, Huang Z, Cai J, Huang W, Lin Y, Ke H, Long J, Zou Y, Ye S, Lan P. Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer. J Biomed Sci. 2023 Jun 28;30(1):47. doi: 10.1186/s12929-023-00930-6. PMID: 37380972; PMCID: PMC10303345.
- Huang H, Guo F, Deng X, Yan M, Wang D, Sun Z, Yuan C, Zhou Q. Modulation of T Cell Responses by Fucoidan to Inhibit Osteogenesis. Front Immunol. 2022 Jun 23;13:911390. doi: 10.3389/fimmu.2022.911390. PMID: 35812368; PMCID: PMC9260855.
ADDITIONAL INFORMATION
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Clone:
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37.51
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Format:
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Purified
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Applications:
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FC, FA, IP
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Reactivity:
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Mouse
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Isotype:
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Golden Syrian Hamster IgG
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | T Cells |
| Application: | FC, FA, IP |
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Preparation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Nandi, D., Gross, J. A., & Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells. The Journal of Immunology, 152(7), 3361-3369. Gross, J. A., Callas, E. L. E. N. I., & Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse. The Journal of Immunology, 149(2), 380-388. Grossi, J. A., Raulet, D. H., & Allison, J. P. (1992). CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.Nature, 356, 607-9. Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., & Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis. The Journal of Immunology,157(10), 4347-4353. |
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