Anti-Human CD28 SAFIRE Purified ( Clone : CD28.2 )
SAFIRE(Sodium Azide Free Immensely Reduced Endotoxin) 제품은 면역세포 activation, blocking, neutralization 연구에 사용할 수 있는 BioGems의 기능성 항체 라인입니다. 이 제품은 career 및 sodium azide 를 전혀 포함하지 않으며, in vivo 및 in vitro 사용가능한 0.01 EU/ug 이하의 내독소 수준으로 제조된 제품입니다.
CD28.2 단일클론 항체는 대부분의 성숙 T 림프구, 혈장 세포 및 흉선 세포의 표면에서 발현되는 인간 44 kDa 동종이량체 막횡단 당단백질 CD28에 대하여 특이적으로 결합합니다.
CD28은 T 림프구의 공동 자극자인 B7-1(CD80)과 B7-2(CD86)에 대한 리간드로써, T 림프구와 B 림프구 사이의 상호 작용을 향상 시킵니다.
IL-2를 생성하기 위한 T 림프구 자극은 관련된 단클론 항체에 달려 있다고 보고되었으며, 이는 CD28 분자가 뚜렷한 기능을 가진 일부 하위 영역을 제공한다는 것을 암시합니다.
CD28.2 항체는 Jurkat T 림프구에서 Ca2 유입을 유도합니다. 다른 연구에서는 CD28이 신호 전달에 관여하는 것으로 나타났습니다.
ADDITIONAL CD28.2 FORMATS
| CAT.NO. | FORMAT | STARTING FROM |
|---|---|---|
| 10311-77 | PE-Cyanine7 | $ 115.00 |
| 10311-20 | Purified | $ 75.00 |
| 10311-25 | SAFIRE Purified | $ 130.00 |
| 10311-50 | FITC | $ 70.00 |
| 10311-80 | APC | $ 105.00 |
| 10311-60 | PE | $ 80.00 |
| 10311-70 | PerCP-Cyanine5.5 | $ 135.00 |
[ 최신 제품 인용 논문]
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ADDITIONAL INFORMATION
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Clone:
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CD28.2
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Format:
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SAFIRE Purified
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Applications:
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FC, FA, IHC, IP
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Reactivity:
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | Adaptive Immunity |
|---|---|
| Cell Type: | T Cells |
| Application: | FC, FA, IHC, IP |
| Clone: | CD28.2 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Nunès, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., … & Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology, 5(3), 311-315. Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., & Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. Journal of virology, 81(24), 13444-13455. |
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